The 6th edition of the Global Micro, Small, and Medium Enterprises (MSMEs) Report by the International Council for Small Business (ICSB) focuses on the transformative role of youth and women entrepreneurship in enhancing supply chains and driving sustainable development. Aligned with the United Nations' Sustainable Development Goals (SDGs), the report highlights the innovative spirit and resilience of young and women entrepreneurs in fostering inclusive growth and equitable opportunities. It emphasizes the concept of humane entrepreneurship, which goes beyond profit to prioritize empathy, ethical practices, and social impact. By exploring inspiring stories, research findings, and practical insights, the report calls for a people-centric approach that nurtures enterprises and champions sustainable practices. It aims to inspire entrepreneurs, policymakers, and stakeholders to support MSMEs in creating a more inclusive and sustainable future, where these enterprises can thrive and drive positive social and economic change.